Fe-Free:
Electromagnetic, unique,
non-invasive Treatment
for antibiotic resistant
Infections and cancer
The Problem
Antibiotic resistant
infections: A Global
Health care
Challenge -affects
countries in all
regions and at all
income levels
Biofilm makes
pathogens resistant
to antibiotics.
Lead to chronic
diseases,
amputations, and
high mortality.
In addition to death
and disability,
antimicrobial
resistance has
significant economic
costs.
The Solution
Disrupting bacterial
colony/Biofilm with
non-invasive
Electromagnetic
Technology
Disrupts iron
consumption essential
for bacterial
colony/biofilm
growth.
POC In Vitro (PAS1)
Results:
Biofilm from P.
aeruginosa showed 71%
fewer live bacteria
vs. control in flow
cell test
No drugs or
consumables needed.
Market Opportunity
•First Medical Indication: Diabetic Chronic Ulcers
Massive Market Opportunity Antibiotic-resistant
infections driven by bacterial biofilms cause
thousands of amputations and deaths each year.
•Global diabetic ulcer treatment market:
8.32B (2019) → 18.41B (2032)
(Source: Fortune Business Insights)
•Fe-Free provides an affordable, non-antibiotic
solution for chronic ulcer care —helping to save
limbs, lives, and significantly reduce pain and
complications.
What's Next?
Medical Indication - Diabetic Chronic Ulcer
Preclinical animal testing
Regulatory submissions (FDA, class 2),
FDA Breakthrough device program
Clinical trials at hospitals.
Customer Validation and product
development
Market entry and hospital
partnerships.
Meet the team
CMO
Co-founder
Tina Weinstein
Tina brings over 20
years of experience in
international marketing,
sales management and
operations in medical
device companies and
medical institutions.
Chief scientist
CO-founder
Dr, Haya Friedman
Haya was a Senior
Scientist and Department
Head at the Agricultural
Research Organization,
Israel. She is an expert
in cellular and molecular
biology
CTO
CO-founder
Itzhak Kremin
Technology and
science. Itzhak
brings over 30 years
of experience in
medical device
engineering, science
and R&D
VP R&D
Co-founder
Vadim Polyakov
Engineering and
technology.
Vadim brings over 30
years of experience in
medical device
engineering, strategy
and R&D
CEO
Co-founder
Yossi Aldar
Yossi brings
an extensive
experience as
CEO and
founder of
medical
device
companies
Iron is necessary for bacterial survival
Dr, Haya Friedman, Fe-Free
Many serious diseases result from antibiotic-resistant bacteria, like Prosthetic Joint infection (PJI), Cystic Fibrosis (CF), or chronic wound
infections, and even cancer (El Tekle, Andreeva et al. 2024). One of the reasons for persistent antibiotic-resistant infection is caused by
bacterial biofilm. The biofilm is a colony embedded in secretions of various molecules, creating a "shield" against the immune system and the
penetration of antibiotics to the vicinity of the bacteria.
Bacteria, like other organisms, need iron for their metabolic processes. Iron exists in nature mainly as ores, but it also exists as Ferrous (Fe+2)
or Ferric (Fe+3) ions. The concentration of free iron available for microbial use in natural environments is deficient and is around 1 × 10−18
mol/L, compared to the 1 × 10−6mol/L required by most microbes. Hence, bacteria developed intricate mechanisms to absorb iron from the
surroundings. There is multiple evidence showing that iron is necessary for biofilm formation and maintenance. Depletion of iron can reduce
biofilm. The fact that bacteria produce specific molecules (siderophores) that can bind iron and facilitate its entry also supports the necessity
of iron for survival (Xie, Wei et al. 2024). Additional support for the importance of iron to bacterial growth comes from the existence of an
innate host mechanism (Hypoferremia) that reduces iron levels upon bacterial infection (Ganz and Nemeth 2024).
REFERENCES
El Tekle, G., et al. (2024). "The role of the microbiome in the etiopathogenesis of colon cancer." Annual Review of Physiology 86(1): 453-478.
Ganz, T. and E. Nemeth (2024). "Hypoferremia of inflammation: Innate host defense against infections." Blood Cells, Molecules, and Diseases
104:102777.
Xie, B., et al. (2024). "Exploring the biological pathways of siderophores and their multidisciplinary applications: A comprehenisve review."
Molecules 29(10): 2318.
