The Double-Edged Sword
Iron ions act as a double-edged sword: on one hand, they enable cellular metabolism and survival, and on the other hand, they can cause ferroptosis—cell death caused by iron overload. This death can occur in cells including bacteria, due to Fenton reaction with ferric ions, which can lead to production of reactive oxygen species (ROS).
Iron Depletion Strategy
Blocking iron entry into the bacterial biofilm is a strategy adopted by many scientists to hinder biofilm creation. A large body of evidence shows that removal of iron by chelators can reduce biofilm and can improve healing caused by infectious bacteria.
When iron entry into bacteria is blocked, it does not only cause biofilm disturbance, but also an increase in the mechanism(s) of iron absorption, like increase of siderophore production and export.
Our Innovative Approach
Fe- Free Medical Technologies has developed a novel electromagnetic approach that prevents bacterial iron uptake at the molecular level, disrupting biofilm formation without the use of chemicals or drugs.
This innovative mechanism targets the fundamental survival requirement of bacteria—their need for iron—making it virtually impossible for them to develop resistance.
Read the Full Research Paper
For a comprehensive understanding of the scientific principles behind our technology, download our complete research paper on iron depletion in bacterial biofilms.
📄
Download Research Paper (PDF)