Clinical-Grade Wound Care

A non-invasive electromagnetic
device for chronic wound infections

Fe-Free targets the root cause of treatment-resistant biofilm infections - without antibiotics, surgery, or chemicals. Validated at Bar-Ilan University.

94.2%

Bacterial reduction demonstrated

P. aeruginosa PAO1 · Bar-Ilan University, 2025

18M

New chronic wound cases globally per year

WHO Global Wound Care Report, 2023

$18.6B

Global chronic wound care market

Grand View Research, 2024

Request Information See how it works ↓

Why chronic wounds resist conventional treatment

Up to 80% of chronic wound infections involve bacterial biofilm - a protective matrix that renders standard antibiotics 1,000 times less effective. Current treatment options are expensive, painful, or logistically prohibitive.

Antibiotic Resistance

Biofilm renders antibiotics 100-1,000 times less effective. Repeated courses accelerate resistance without resolving the underlying infection.

Vacuum Therapy (NPWT)

NPWT manages fluid and symptoms but does not target biofilm. Ineffective at toe, heel, and interdigital sites - where most DFU occur.

Hyperbaric Oxygen

Requires pressurized chambers and specialized facilities. High cost and limited access make it impractical for most patients.

The AMR Dimension

The WHO classifies antimicrobial resistance as one of the top ten global health threats. Diabetic foot ulcers are a primary driver of antibiotic overuse.

World Health Organization. Global antimicrobial resistance and use surveillance system (GLASS) report, 2022.

Only 50%

of chronic wounds heal under standard care

85%

of lower-limb amputations begin as a foot ulcer

Magneto-Kinetic Excitation - a physics-based approach

Rather than attacking bacteria chemically, Fe-Free deprives them of iron - an absolute physiological necessity for bacterial survival, biofilm formation, and quorum sensing. Iron is a chemical element; bacteria cannot develop genetic resistance to its absence.

MKE Technology

Iron starvation - resistance-proof by mechanism

The MKE field interferes with siderophore-mediated iron uptake - the mechanism bacteria rely on to build and sustain biofilm. Deprived of iron, bacteria lose the capacity to maintain biofilm structure or coordinate collective defense. The matrix collapses.

PEMF Healing

Tissue regeneration - 20 years of clinical use

Integrated PEMF stimulates microcirculation and cellular repair - an established modality with a two-decade clinical safety profile. Both mechanisms operate within a single non-invasive treatment session.

Treatment in four steps

Field Generation

The device generates a precision-tuned electromagnetic field around the wound area. No direct contact with tissue is required.

Siderophore Excitation

The field interacts with ionic transport and redox-related processes involved in bacterial siderophore-mediated iron acquisition.

Binding Disruption

Iron uptake is impaired. Bacteria enter iron starvation and lose the capacity to maintain biofilm structure and integrity.

Healing Acceleration

As biofilm collapses and bacteria die, concurrent PEMF stimulation activates the body's natural tissue repair mechanisms.

Clinical and laboratory evidence

Fe-Free's mechanism has been validated in controlled laboratory studies by leading research institutions. Phase 2 optimization is planned for 2026.

Bar-Ilan University, 2025

94.2%

Bacterial reduction in controlled laboratory studies

Research conducted by Prof. Ehud Banin, a recognized international authority in biofilm biology, demonstrated significant bacterial reduction against resistant strains of Pseudomonas aeruginosa PAO1 - one of the most treatment-resistant biofilm-forming pathogens in chronic wounds.

Bar-Ilan University, Faculty of Life Sciences. In vitro study, 2024. Phase 2 studies targeting ≥90% reduction are planned for 2026.

Download Research Paper

Iron as a fundamental target

Iron regulates three interdependent systems in bacterial survival: biofilm matrix gene expression, cellular respiration and ATP synthesis, and quorum sensing signal coordination. Disrupting iron uptake collapses all three simultaneously.

Lower resistance risk by mechanism

Unlike antibiotic targets, which bacteria can circumvent through gene mutation, iron is an elemental physiological requirement. Resistance risk is expected to be lower - a hypothesis being tested in ongoing research.

Safe for human tissue

Human cells regulate iron via transferrin-mediated pathways, not siderophores. The MKE frequency parameters are tuned to bacterial siderophore resonance exclusively. Human iron metabolism is unaffected at therapeutic field intensities.

“

The electromagnetic iron starvation mechanism is an interesting and promising scientific approach that addresses a meaningful gap in our current treatment options.

Dr. Oran Schachter, DPM

Podiatric Surgeon - Diabetic Foot Clinic, Rambam Medical Center

Safety and selectivity profile

MKE operates within ELF/VLF frequency ranges. The device generates no thermal effect, no ionizing radiation, and introduces no chemical agents into the body.

Non-Thermal

No elevation in tissue temperature at therapeutic field intensities. Zero risk of thermal injury to surrounding or underlying tissue.

Frequency-Specific

Field parameters are calibrated to bacterial siderophore resonance. Human iron metabolism - regulated via transferrin, not siderophores - is unaffected.

Non-Ionizing

Operates at extremely low frequency (ELF) and very low frequency (VLF) ranges. No ionizing radiation. No cumulative radiation exposure risk with repeated treatment sessions.

Chemical-Free

No drugs, antibiotics, or chemical agents are introduced into the body. No systemic exposure. No drug-drug interaction considerations.

Leadership

60+ years of combined medical device development, regulatory clearance, and clinical research experience.

Yossi Aldar

CEO & Co-Founder

Serial MedTech entrepreneur with four successful exits including Syqe Medical (Philip Morris), SteadyMed (United Therapeutics), and VersaMed (GE Healthcare). Five registered patents, multiple FDA clearances.

Dr. Haya Friedman

Chief Scientist & Co-Founder

PhD in Biology (Hebrew University), Postdoctoral Fellow at Yale University. Professor Emeritus with 25+ years of senior research. 69 peer-reviewed publications in cellular biology and immunology.

Itzhak Kremin

CTO & Co-Founder

30+ years of medical device R&D. Co-inventor of four US patents in electromagnetic therapy systems. Former CTO at OrthopCure and Venus Concept, specializing in EM and PEMF device development.

Tina Weinstein

CMO & Co-Founder

20+ years of international marketing, sales management, and commercial operations across medical device companies and clinical institutions in Europe and the United States.

Vadim Polyakov

R&D & Co-Founder

30+ years of experience in medical device engineering, strategic R&D planning, and advanced technology development.

Dr. Matityahu Noff, MD

Medical Advisor

Orthopedic foot surgeon with 30+ years specializing in diabetic foot ulcers. Founder and past president of the Israeli Society for Foot & Ankle. Director of DFU Clinics at Shaare Zedek Medical Center, Jerusalem.

For Treating Physicians

Addressing DFU infection at the biofilm level

Fe-Free is a physical, drug-free adjunct to standard wound care - targeting biofilm directly without increasing antimicrobial pressure or introducing systemic drug burden.

Request Clinical Information

Biofilm in DFU - the clinical burden

Biofilm correlates with delayed closure, recurrent infection, and amputation risk. Debridement alone is insufficient - bacterial colonies re-establish within 24-72 hours.

Schultz G et al. Wound biofilm consensus document. Wound Repair Regen. 2017.

The science of iron depletion in biofilm

By Dr. Haya Friedman, Chief Scientist & Co-Founder, Fe-Free Medical Technologies.

Iron's role in bacterial survival

Iron is essential for bacterial metabolism, biofilm gene expression, quorum sensing, and cellular respiration. When iron entry is blocked, bacteria upregulate siderophore production in a desperation response - Fe-Free disrupts this at the binding step, collapsing the entire iron acquisition chain.

Iron depletion by chelators has a substantial evidence base across multiple bacterial species. Fe-Free achieves the same outcome through a physical, not chemical, mechanism.

Key scientific principle

Iron depletion does not only disturb biofilm structure - it simultaneously impairs the bacteria's capacity to sense and respond to their environment, coordinate collective defense, and maintain the energetic requirements of infection persistence.

Weinberg ED. Iron availability and infection. Biochim Biophys Acta. 2009.

Access the full research

Download the complete research paper on iron depletion in bacterial biofilms, including mechanism review, experimental data, and literature citations.

Download Research Paper (PDF)

Platform potential - beyond chronic wounds

The Magneto-Kinetic Excitation mechanism is not wound-specific. Any infection site accessible to an electromagnetic field, where bacterial biofilm is the primary treatment obstacle, represents a potential application.

Diabetic Foot Ulcers

Primary indication. Wound accessibility, defined outcome measures, and significant unmet clinical need make DFU the optimal initial regulatory pathway.

Implant-Associated Infections

Biofilm on orthopedic implants and cardiac devices is a major driver of treatment failure and reoperation. A non-invasive physical intervention addresses this without revision surgery.

Deep Tissue Infections

Antibiotic-resistant organisms in deep soft tissue present limited options. Resistance-proof iron starvation offers a mechanism that functions regardless of antibiotic sensitivity profile.

$100B+

Global biofilm-associated infection market

MKE addresses a universal biological problem - bacterial iron dependence - across any infection site accessible to an electromagnetic field. DFU is the entry point.

News & Updates

Accelerator · August 2026

Fe-Free Joins Dan Launchpad Venture-in-Residence Program at Tel Aviv University

Fe-Free has been accepted into the Venture-in-Residence (VIR) track at Dan Launchpad, Tel Aviv University - a selective program for high-potential deep-tech ventures. Being part of this innovation ecosystem is an important opportunity to accelerate our development, connect with mentors and industry experts, and advance our technology toward clinical validation.

Research · July 2026

Phase 2 Interim Results - Significant Bacterial Reduction Achieved

Ongoing research at Bar-Ilan University in the laboratory of Prof. Ehud Banin has demonstrated a significant reduction in bacterial load in our latest experiments, with highly encouraging results. These findings represent another important step in the development of our non-invasive iron-starvation technology for bacterial biofilm and antimicrobial resistance.

We are grateful to Prof. Banin and his team for their continued collaboration.

Contact Fe-Free Medical Technologies

For clinical partnership inquiries, investor relations, or research collaboration, contact us directly. We respond to all substantive inquiries within one business day.

info@fe-free.com

Website

www.fe-free.com

Location

Israel

LinkedIn Facebook

Request Information

Whether you are a wound-care physician, a potential investor, or a research institution, we welcome your inquiry.

A non-invasive electromagneticdevice for chronic wound infections